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Science 4 October 1974:
Vol. 186. no. 4158, pp. 55 - 57
DOI: 10.1126/science.186.4158.55
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Articles

Serum Globulin in Myasthenia Gravis: Inhibition of agr-Bungarotoxin Binding to Acetylcholine Receptors

Richard R. Almon 1, Clifford G. Andrew 1, and Stanley H. Appel 1

1 Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710

Serum factors that inhibit the binding of 125I-labeled agr-bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Effect of myasthenic immunoglobulin on acetylcholine receptors of intact mammalian neuromuscular junctions.
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Clinical Syndromes of Myasthenia in Infancy and Childhood: A Review.
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Arch Neurol 35, 97-103
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Binding of Iodine 125 {alpha}-Bungarotoxin to the Thymus of Mice.
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Myasthenic immunoglobulin accelerates acetylcholine receptor degradation.
I Kao and D. Drachman (1977)
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Receptors for Peptide Hormones: New Insights into the Pathophysiology of Disease States in Man.
C. R. KAHN, K. MEGYESI, R. S. BAR, R. C. EASTMAN, and J. S. FLIER (1977)
Ann Intern Med 86, 205-219
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Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis.
I Kao and D. Drachman (1977)
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Myasthenia gravis: passive transfer from man to mouse.
K. Toyka, D. Brachman, A Pestronk, and I Kao (1975)
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Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)