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Science 20 September 1974:
Vol. 185. no. 4156, pp. 1067 - 1069
DOI: 10.1126/science.185.4156.1067
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Articles

Fenfluramine: Amphetamine Congener That Fails to Maintain Drug-Taking Behavior in the Rhesus Monkey

James H. Woods 1 and Richard E. Tessel 1

1 Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48104

Fenfluramine, over a dose range from 0.003 to 3 milligrams per kilogram of body weight, failed to maintain self-injection behavior in rhesus monkeys that had initiated and maintained responding for cocaine or methohexital. This absence of a positive reinforcing effect could not be attributed to a slow onset of drug effect or to the use of behaviorally inactive doses. Fenfluramine, because of its distinctive properties, may produce fewer problems of human abuse than do amphetamine-type agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration.
R. B. Rothman, B. E. Blough, W. L. Woolverton, K. G. Anderson, S. S. Negus, N. K. Mello, B. L. Roth, and M. H. Baumann (2005)
J. Pharmacol. Exp. Ther. 313, 1361-1369
   Abstract »    Full Text »    PDF »
Double-blind Evaluation of Reinforcing and Anorectic Actions of Weight Control Medications: Interaction of Pharmacological and Behavioral Treatments.
G. E. Bigelow, R. R. Griffiths, I. Liebson, and J. E. Kaliszakn (1980)
Arch Gen Psychiatry 37, 1118-1123
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)