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Science 20 September 1974:
Vol. 185. no. 4156, pp. 1060 - 1061
DOI: 10.1126/science.185.4156.1060
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Articles

Puromycin: A Questionable Drug for Studying the Mechanism of Thyroid Calorigenesis in vivo

Glenda E. Bilder 1 and W. Donner Denckla 1

1 Roche Institute of Molecular Biology, Nutley, New Jersey 07110

Puromycin fails to alter minimal oxygen consumption of rats treated with thyroxine, provided the rectal temperatures of these rats are maintained at 37.8° to 38.1°C. The previously reported puromycin-induced decline in basal metabolic rate of thyroxine-treated rats may have been due to the hypothermia produced by this drug.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)