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Science 20 September 1974:
Vol. 185. no. 4156, pp. 1049 - 1053
DOI: 10.1126/science.185.4156.1049
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Articles

Reoviruslike Agent in Stools: Association with Infantile Diarrhea and Development of Serologic Tests

Albert Z. Kapikian 1, Hyun Wha Kim 2, Richard G. Wyatt 3, William J. Rodriguez 4, Sydney Ross 4, W. Lee Cline 3, Robert H. Parrott 4, and Robert M. Chanock 3

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Children's Hospital, Washington, D.C. 20009
3 National Institute of Allergy and Infectious Diseases
4 Children's Hospital

Reoviruslike particles were visualized by electron microscopy in stool filtrates prepared from stools of infants and young children with severe acute gastroenteritis. Patients who had such particles in their stools and whose paired acute and convalescent serums were tested developed an antibody response to the reoviruslike agent, which was measured by immune electron microscopy and by complement fixation. The reoviruslike agent was antigenically related to the epizootic diarrhea of infant mice virus and the Nebraska calf diarrhea virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enzyme-linked immunosorbent assay for identification of rotaviruses from different animal species.
R. Yolken, B Barbour, R. Wyatt, A. Kalica, A. Kapikian, and R. Chanock (1978)
Science 201, 259-262
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Science. ISSN 0036-8075 (print), 1095-9203 (online)