Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 September 1974:
Vol. 185. no. 4155, pp. 955 - 957
DOI: 10.1126/science.185.4155.955
Prev | Table of Contents | Next

Articles

MIF-Like Activity in Simian Virus 40-Transformed 3T3 Fibroblast Cultures

M. Elizabeth Hammond 1, Richard O. Roblin 1, Ann M. Dvorak 1, Salvatore S. Selvaggio 1, Paul H. Black 1, and Harold F. Dvorak 1

1 Departments of Pathology, Microbiology and Molecular Genetics, and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston 02114, and Department of Pathology, Tufts University Medical School, Boston 02111

Simian virus 40-transformed fibroblasts (SV3T3), as compared with their untransformed counterparts (3T3), elaborate a macromolecular product that inhibits macrophage migration and causes macrophages to aggregate and lose one type of cell coat material. I'he SV3T3 cells also lack this surface material relative to 3T3 cells. There may be a relationz between migration inhibition factor (MIF), the cell coat, and cell migration.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)