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Science 13 September 1974:
Vol. 185. no. 4155, pp. 946 - 948
DOI: 10.1126/science.185.4155.946
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Articles

Hemoglobin Switching in Sheep and Goats: Occurrence of Hemoglobins A and C in the Same Red Cell

Arthur W. Nienhuis 1 and H. Franklin Bunn 2

1 Section on Clinical Hematology, National Heart and Lung Institute, Bethesda, Maryland 20014
2 Division of Hematology, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Sheep and goats switch from the synthesis of hemoglobin A (agr2beta2A) to hemoglobin C (agr2beta2C) when made anemic. We have demonstrated the existence of the asymmetrical hybrid hemoglobin, agr2betaAbetaC, in the circulating red cells of anemic sheep. These erythroid cells, therefore, synthesized both A and C hemoglobin simultaneously. Thus, the switch appears to be mediated by selective gene expression rather than by a clonal or cellular selective mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stability of the individual globin genes during erythroid differentiation.
E Benz Jr, P Turner, J Barker, and A Nienhuis (1977)
Science 196, 1213-1214
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