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Science 6 September 1974:
Vol. 185. no. 4154, pp. 862 - 864
DOI: 10.1126/science.185.4154.862
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Articles

Amino Acid Difference Formula to Help Explain Protein Evolution

R. Grantham 1

1 Laboratoire de Biométrie, Université Lyon 1, 69 Villeurbanne, France

A formula for diference between amino acids combines properties that correlate best with protein residue substitution frequencies: composition, polarity, and molecular volume. Substitution frequencies agree much better with overall chemical difference between exchanging residues than with minimum base changes between their codons. Correlation coefficients show that fixation of mutations between dissimilar amino acids is generally rare.


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P. D. Evans, J. R. Anderson, E. J. Vallender, S. S. Choi, and B. T. Lahn (2004)
Hum. Mol. Genet. 13, 1139-1145
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Inferring the Evolutionary History of Rice Yellow Mottle Virus from Genomic, Phylogenetic, and Phylogeographic Studies.
D. Fargette, A. Pinel, Z. Abubakar, O. Traore, C. Brugidou, S. Fatogoma, E. Hebrard, M. Choisy, Y. Sere, C. Fauquet, et al. (2004)
J. Virol. 78, 3252-3261
   Abstract »    Full Text »    PDF »
Phylogenetic Estimation of Context-Dependent Substitution Rates by Maximum Likelihood.
A. Siepel and D. Haussler (2004)
Mol. Biol. Evol. 21, 468-488
   Abstract »    Full Text »    PDF »
TopNet: a tool for comparing biological sub-networks, correlating protein properties with topological statistics.
H. Yu, X. Zhu, D. Greenbaum, J. Karro, and M. Gerstein (2004)
Nucleic Acids Res. 32, 328-337
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Patterns of Nucleotide Polymorphism and Divergence in the Odorant-Binding Protein Genes OS-E and OS-F: Analysis in the Melanogaster Species Subgroup of Drosophila.
A. Sanchez-Gracia, M. Aguade, and J. Rozas (2003)
Genetics 165, 1279-1288
   Abstract »    Full Text »    PDF »
Adaptive Evolution of MRG, a Neuron-Specific Gene Family Implicated in Nociception.
S. S. Choi and B. T. Lahn (2003)
Genome Res. 13, 2252-2259
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Single Nucleotide Variation Analysis in 65 Candidate Genes for CNS Disorders in a Representative Sample of the European Population.
Y. Freudenberg-Hua, J. Freudenberg, N. Kluck, S. Cichon, P. Propping, and M. M. Nothen (2003)
Genome Res. 13, 2271-2276
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PANTHER: A Library of Protein Families and Subfamilies Indexed by Function.
P. D. Thomas, M. J. Campbell, A. Kejariwal, H. Mi, B. Karlak, R. Daverman, K. Diemer, A. Muruganujan, and A. Narechania (2003)
Genome Res. 13, 2129-2141
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