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Science 30 August 1974:
Vol. 185. no. 4153, pp. 789 - 791
DOI: 10.1126/science.185.4153.789
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Articles

Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption

Lawrence G. Raisz 1, Ann L. Sandberg 2, J. Max Goodson 3, Hollis A. Simmons 4, and Stephan E. Mergenhagen 5

1 Departments of Pharmacology and Toxicology and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
2 Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland 20014
3 University of California School of Dentistry, San Francisco 94122
4 University of Rochester School of Medicine and Dentistry
5 Laboratory of Microbiology and Immunology, National Institute of Dental Research

Complement-sufficient heterologous serum induced prostaglandin synthesis and resultant resorption in cultures of fetal rat long bones. Bone resorption was enhanced with unheated normal rabbit serum as compared to heated serum or serum from rabbits lacking the sixth component of complement (C6). Addition of functionally purified C6 restored resorptive activity in C6-deficient serum. Concentrations of prostaglandin E were increased in the culture media of bones incubated with complement-sufficient serum. The resorptive effects of active serum as well as the appearance of prostaglandin E in the media were inhibited by indomethacin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Detection of Functional Complement Components in Gingival Crevicular Fluid from Humans with Periodontal Disease.
F. J. Courts, R. J. Boackle, H. H. Fudenberg, and M. S. Silverman (1977)
Journal of Dental Research 56, 327-331
   Abstract »    PDF »
Spleen cells transmit osteopetrosis in mice.
D. Walker (1975)
Science 190, 785-787
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)