Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 30 August 1974:
Vol. 185. no. 4153, pp. 784 - 787
DOI: 10.1126/science.185.4153.784
Prev | Table of Contents | Next

Articles

Computer-Assisted Analysis of Chromosomal Abnormalities: Detection of a Deletion in Aniridia/ Wilms' Tumor Syndrome

R. Ladda 1, L. Atkins 1, J. Littlefield 1, P. Neurath 2, and K. M. Marimuthu 2

1 Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114
2 Department of Therapeutic Radiology, Tufts University-New England Medical Center, Boston 02111

A chromosome translocation, t(8p + ; 11q -), in a patient with aniridia and Wilms' tumor, appeared balanced by standard techniques, including trypsin banding. Computer analysis of optical microscope scanning profiles of chromosome pairs 8 and 11 revealed an interstitial deletion of the short arm of 8. Computer analysis coupled to the new banding techniques provides greater resolution for the detection of subtle chromosomal variations not recognized by banding methods alone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The approaching era of the tumor suppressor genes.
G Klein (1987)
Science 238, 1539-1545
   Abstract »    PDF »
Wilms' Tumor in a 13-Year-Old Girl With Trisomy 18.
G. KARAYALCIN, A. SHANSKE, and R. HONIGMAN (1981)
Arch Pediatr Adolesc Med 135, 665-667
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)