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Science 16 August 1974:
Vol. 185. no. 4151, pp. 612 - 614
DOI: 10.1126/science.185.4151.612
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Articles

Genetic Variation in Coumarin Hydroxylase Activity in the Mouse (Mus musculus)

A. W. Wood 1 and A. H. Conney 1

1 Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110

Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F1 hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of CYP2A5 Gene by the Transcription Factor Nuclear Factor (Erythroid-Derived 2)-Like 2.
A. Abu-Bakar, V. Lamsa, S. Arpiainen, M. R. Moore, M. A. Lang, and J. Hakkola (2007)
Drug Metab. Dispos. 35, 787-794
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Science. ISSN 0036-8075 (print), 1095-9203 (online)