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Science 9 August 1974:
Vol. 185. no. 4150, pp. 529 - 531
DOI: 10.1126/science.185.4150.529
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Articles

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

Joe M. McCord 1

1 Departmnents of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710

Enzymatically genierated superoxide radical. by reactitng with hydrogen peroxide to prduce the hydroxyl radical, depolymerized puirified hyaluronic acid and bovine synovial flulid. Since phagocytizing polymorphonuclear leukocytes produce superoxide radicals, this reac-tion is sutggested and shown to be quantitatively feasible as the ini vivo mechanism of synovial fluid degradation in anl inflamed joint. Superoxide dismutase, and catalase protect synaovial fluid against such degradation in vitro.


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