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Science 9 August 1974:
Vol. 185. no. 4150, pp. 527 - 528
DOI: 10.1126/science.185.4150.527
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Articles

5-Hydroxyindoleacetic Acid in the Lumbar Fluid: A Specific Indicator of Spinal Cord Injury

M. Bulat 1, Z. LackoviCacute 1, M. JakupCcaroneviCcaron 1, and I. Damjanov 2

1 Institut Rudjer BoScaronkoviCacute, BijeniCcaronka 54, 41001 Zagreb, Yugoslavia
2 Department of Pathology, Medical School, University of Zagreb, Zagreb

In cats, 19 days after the lower thoracic cord was injllred, the concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid in the lumbosacral cord and that of 5-hydroxyindoleacetic acid in the lumbar fluid decreased. At the same time the concentrations of these substances in the cord above the lesion and that of 5-hydroxyindoleacetic acid in the cisternal fluid was not significantly altered. Since high concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid are present in the human lumbosacral cord, it appears that the concentration of 5-hydroxyincdoleacetic acid in the lumbar fluid of animals and man reflects the biochemical changes of 5-hydroxytryptamine in the spinal cord.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Homovanillic Acid and 5-Hydroxyindoleacetic Acid Cerebrospinal Fluid Levels: A Study With and Without Probenecid Administration of Their Relationship to the State of Consciousness After Head Injury.
C. J. Vecht, T. C.A.M. van Woerkom, A. W. Teelken, and J. M. Minderhoud (1975)
Arch Neurol 32, 792-797
   Abstract »    PDF »
Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia.
R. M. Post, E. Fink, W. T. Carpenter Jr, and F. K. Goodwin (1975)
Arch Gen Psychiatry 32, 1063-1069
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)