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Science 2 August 1974:
Vol. 185. no. 4149, pp. 451 - 453
DOI: 10.1126/science.185.4149.451
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Articles

Amphetamine Effects in Man: Paradoxical Drowsiness and Lowered Electrical Brain Activity (CNV)

Joseph J. Tecce 1 and Jonathan O. Cole 1

1 Laboratory of Neuropsychology, Boston State Hospital, Boston, Massachusetts 02124, and Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts 02111

Thirteen of 20 normal adults given 10 milligrams of dextroamphetamine exhibited paradoxical drowsiness accompanied by lowered electrical brain activity (contingent negative variation, or CNV) in the first hour post-drug. During this period, seven subjects showed behavioral alertness and increased CNV amplitude. Both groups of subjects showed heightened alertness 2 and 3 hours post-drug. Amphetamine is not a simple stimulant of the central nervous system but can also act as a depressant.


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