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Science 2 August 1974:
Vol. 185. no. 4149, pp. 449 - 451
DOI: 10.1126/science.185.4149.449
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Articles

Reversal of Morphine Tolerance after Medial Thalamic Lesions in the Rat

Herman Teitelbaum 1, George N. Catravas 1, and Willard L. McFarland 1

1 Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, Bethesda, Maryland 20014

Tolerance, manifested by a diminished electroencephalographic response at cortical and subcortical recording sites, was found in rats subjected to repeated systemic injections of morphine sulfate. Reversal of tolerance to morphine resulted from destruction of the medial thalamus.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)