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Science 19 July 1974:
Vol. 185. no. 4147, pp. 274 - 277
DOI: 10.1126/science.185.4147.274
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Articles

Gelation of Sickle Cell Hemoglobin: Effects of Hybrid Tetramer Formation in Hemoglobin Mixtures

Keith Moffat 1

1 Section of Biochemistry, Molecular and Cell Biology, Cornell University. Ithaca, New York 14850

The altered gelation behavior found in mixtures of sickle cell hemoglobin with other hemoglobins is due to the formation of hybrid hemoglobin tetramers from unlike dimers. The hemoglobins need not possess the deoxy quaternary structure for gelation to occur; liganded forms are also capable of participation in gelation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)