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Science 19 July 1974:
Vol. 185. no. 4147, pp. 267 - 269
DOI: 10.1126/science.185.4147.267
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Articles

Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain

Michael J. Brownstein 1, Miklos Palkovits 1, Juan M. Saavedra 1, Rabim M. Bassiri 2, and Robert D. Utiger 2

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
2 Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104

The regional distribution of thyrotropin-releasing hormone (TRH) in rat brain was studied. The greatest concentration of TRH was found in the median eminence. High concentrations were also found in several hypothalamic nuclei. Outside the hypothalamus, relatively large amounts of TRH were found in the septal and preoptic areas.


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