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Science 19 July 1974:
Vol. 185. no. 4147, pp. 265 - 267
DOI: 10.1126/science.185.4147.265
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Articles

Thyrotropin-Releasing Hormone: Regional Distribution in Rat Brain

A. Winokur 1 and R. D. Utiger 1

1 Departments of Psychiatry, Pharmacology, and Medicine, University of Pennsylvania School of Medicine, Philadelphia 19174

A sensitive and specific radioimmnunoassay has been used to measure the distribution of thyrotropin-releasing hormone (TRH) in rat brain. All areas of brain tested, except cerebellum, contained readily measurable amounts of TRH. The hypothalamus contained only 31.2 percent of the total brain content of TRH. These results support recent suggestions of central actions for TRH in addition to its hypophysiotropic functions.


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Behavioral and Endocrine Responses of Schizophrenic Patients to TRH (Protirelin).
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Biologically active pituitary hormones in the rat brain amygdaloid nucleus.
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S. Reichlin (1975)
Arch Intern Med 135, 1350-1361
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Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain.
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Science 185, 267-269
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