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Science 5 July 1974:
Vol. 185. no. 4145, pp. 70 - 72
DOI: 10.1126/science.185.4145.70
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Articles

Failure of Beta-Adrenergic Receptor Blockade to Prevent Arrhythmias Induced by Sympathetic Nerve Stimulation

Richard A. Gillis 1, David L. Pearle 1, and Theodore Hoekman 1

1 Departments of Pharmacology and Cardiology, Georgetown University, Schools of Medicine and Dentistry, Washington, D.C. 20007

Cardiac arrhythmias produced by electrical stimulation of the ventrolateral cardiac sympathetic nerve in dogs were not blocked by the combined administration of propranolol and practolol in amounts that completely blocked cardiac beta-adrenergic receptors. Blockade of cardiac alpha-adrenergic receptors, as well as cardiac cholinergic receptors, also had no influence on the arrhythmias. These results suggest that the adrenergic neuroeffector junction is fundamentally different from any hitherto described, differing perhaps in the neurotransmitter involved or in the nature of the receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurocardiology: An Interdisciplinary Area for the 80s.
B. H. Natelson (1985)
Arch Neurol 42, 178-184
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Science. ISSN 0036-8075 (print), 1095-9203 (online)