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Science 5 July 1974:
Vol. 185. no. 4145, pp. 68 - 69
DOI: 10.1126/science.185.4145.68
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Articles

Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Guérin in BALB/c Mice

Robert P. Faraci 1 and Lionel Schour 1

1 Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Uvea.
G. R. O'Connor (1975)
Arch Ophthalmol 93, 675-691
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BCG inhibition of melanoma: specific?.
G. Bartlett and J. Kreider (1975)
Science 188, 1322
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)