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Science 14 June 1974:
Vol. 184. no. 4142, pp. 1187 - 1188
DOI: 10.1126/science.184.4142.1187
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Articles

Taurine Concentrations in Congestive Heart Failure

Ryan Huxtable 1 and Rubin Bressler 1

1 Department of Pharmacology, Arizona Medical Center, Tucson 85721

The concentration of taurine in the left ventricular muscle of hearts of patients who died of chronic congestive heart failure was twice that of patients who died of other causes and had no cardiac pathology. There was no corresponding difference in taurine concentrations in aortic tissue between the two groups. Stress-induced hypertension in rats also led to an increase in taurine concentration in the heart, whereas that in skeletal muscle and brain showed no significant alteration when compared to unstressed animals. Spontaneously hypertensive rats, of the Wistar-derived Okamato strain, showed a similar elevation in cardiac taurine compared to age-matched control Wistar rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy.
P. Pion, M. Kittleson, Q. Rogers, and J. Morris (1987)
Science 237, 764-768
   Abstract »    PDF »
Adrenergic stimulation of taurine transport by the heart.
R Huxtable and J Chubb (1977)
Science 198, 409-411
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)