Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 June 1974:
Vol. 184. no. 4142, pp. 1185 - 1187
DOI: 10.1126/science.184.4142.1185
Prev | Table of Contents | Next

Articles

Latent Ganglionic Infection with Herpes Simplex Virus Types 1 and 2: Viral Reactivation in vivo after Neurectomy

M. Antoinette Walz 1, Richard W. Price 2, and Abner Louis Notkins 3

1 Laboratory of Oral Medicine, National Institute of Dental Research, Bethesda, Maryland 20014
2 Medical Neurology Branch, National Institutes of Neurological Diseases and Stroke, Bethesda, Maryland 20014
3 Laboratory of Oral Medicine, National Institute of Dental Research

Inoculation of the cornea, lip, or footpad of mice with herpes simplex virus type 1 resulted in a latent infection of the local sensory ganglia. Inoculation of the vagina and cervix with herpes simplex virus type 2, as well as type 1, also induced a latent ganglionic infection. With the use of sciatic nerve section as a stimulus, a reproducible model of viral reactivation in vivo was established.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Laser-Capture Microdissection: Refining Estimates of the Quantity and Distribution of Latent Herpes Simplex Virus 1 and Varicella-Zoster Virus DNA in Human Trigeminal Ganglia at the Single-Cell Level.
K. Wang, T. Y. Lau, M. Morales, E. K. Mont, and S. E. Straus (2005)
J. Virol. 79, 14079-14087
   Abstract »    Full Text »    PDF »
Repression of viral transcription during herpes simplex virus latency.
C. M. Preston (2000)
J. Gen. Virol. 81, 1-19
   Full Text »
Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation.
E. Cantin, B. Tanamachi, and H. Openshaw (1999)
J. Virol. 73, 3418-3423
   Abstract »    Full Text »
The Quantity of Latent Viral DNA Correlates with the Relative Rates at Which Herpes Simplex Virus Types 1 and 2 Cause Recurrent Genital Herpes Outbreaks.
J. A. Lekstrom-Himes, L. Pesnicak, and S. E. Straus (1998)
J. Virol. 72, 2760-2764
   Abstract »    Full Text »    PDF »
Molecular Aspects of Herpes Simplex Virus I Latency, Reactivation, and Recurrence.
C.S. Miller, R.J. Danaher, and R.J. Jacob (1998)
Critical Reviews in Oral Biology & Medicine 9, 541-562
   Abstract »    Full Text »    PDF »
Enhanced Replication of Herpes Simplex Virus Type 1 in Human Cells.
C.S. Miller and K.O. Smith (1991)
Journal of Dental Research 70, 111-117
   Abstract »    PDF »
Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice.
K. Cremer, M Mackett, C Wohlenberg, A. Notkins, and B Moss (1985)
Science 228, 737-740
   Abstract »    PDF »
Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation.
T Sekizawa, H Openshaw, C Wohlenberg, and A. Notkins (1980)
Science 210, 1026-1028
   Abstract »    PDF »
6-Hydroxydopamine potentiates acute herpes simplex virus infection of the superior cervical ganglion in mice.
R. Price (1979)
Science 205, 518-520
   Abstract »    PDF »
Herpesvirus in Sensory and Autonomic Ganglia After Eye Infection: Absence of Chronic Viral Shedding.
R. G. Martin, C. R. Dawson, P. Jones, B. Togni, C. Lyons, and J. O. Oh (1977)
Arch Ophthalmol 95, 2053-2056
   Abstract »    PDF »
Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization.
R. Price, M. Walz, C Wohlenberg, and A. Notkins (1975)
Science 188, 938-940
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)