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Science 7 June 1974:
Vol. 184. no. 4141, pp. 1081 - 1083
DOI: 10.1126/science.184.4141.1081
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Articles

Nicotine Inhibition of the Metabolism of 3,4-Benzopyrene, a Carcinogen in Tobacco Smoke

Rocky P. Weber 1, Julius M. Coon 1, and Anthony J. Triolo 1

1 Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

A decreased rate of biliary excretion of radioactive metabolites of 3,4-benzopyrene was observed in rats given a single dose of nicotine. Prior treatment of rats with nicotine decreased benzopyrene hydroxylase activity in homogenates of liver, lung, and small intestine. The addition of nicotine to incubated tissues also decreased benzopyrene hydroxylase activity. These findings show that nicotine inhibits the metabolism of 3,4-benzopyrene in vivo and in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cigarette Abstinence, Nicotine Gum, and Theophylline Disposition.
B. L. LEE, N. L. BENOWITZ, and P. JACOB III (1987)
Ann Intern Med 106, 553-555
   Abstract »    PDF »


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