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Science 31 May 1974:
Vol. 184. no. 4140, pp. 994 - 996
DOI: 10.1126/science.184.4140.994
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Articles

Angiotensin II- and Angiotensin III-Induced Aldosterone Release in vivo in the Rat

William B. Campbell 1, Stephen N. Brooks 1, and William A. Pettinger 1

1 Departments of Pharmacology and Internal Medicine, University of Texas Southwestern Medical School, Dallas

The potential role of angiotensin II and its heptapeptide metabolite, des-aspartyl-angiotensin II, was studied in the conscious unanesthetized rat. Aldosterone release was induced by both peptides at physiologic doses (0.72 nanogram per minute). [I-Sarcosyl-8-alanyl]-angiotensin II (P-113 inhibited angiotensin II more effectively than des-aspartyl-angiotensin II (101 percent as compared to 82 percent). These results indicate that angiotensin controls aldosterone release in the rat and that des-aspartyl-angiotensin II (that is, angiotensin III) may be important in this sequence.


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Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion.
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