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Science 17 May 1974:
Vol. 184. no. 4138, pp. 795 - 797
DOI: 10.1126/science.184.4138.795
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Articles

Serum Induced Lymphoid Cell Mediated Cytotoxicity to Human Transitional Cell Carcinomas of the Genitourinary Tract

Thomas R. Hakala 1 and Paul H. Lange 1

1 Department of Surgery/ Urology, Veterans Administration Hospital, Minneapolis, Minnesota 55417, and Department of Urologic Surgery, University of Minnesota, Minneapolis 55455

In some serums of patients with transitional cell carcinoma (TCC), a factor is present which induces lymphocytes from most donors with or without TCC to become cytotoxic against TCC-derived target cells. The induced cytotoxicity was directed against target cells derived from TCC's of the renal pelvis, ureter, and urinary bladder, but not against cells derived from normal kidney, bladder, testis, or skin or from renal cell carcinoma. Cytotoxicity occurred without complement but did not occur without effector cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunotherapy and Human Tumor Immunology.
J. L. FAHEY, S. BROSMAN, R. C. OSSORIO, C. O'TOOLE, and J. ZIGHELBOIM (1976)
Ann Intern Med 84, 454-465
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Science. ISSN 0036-8075 (print), 1095-9203 (online)