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Science 3 May 1974:
Vol. 184. no. 4136, pp. 572 - 573
DOI: 10.1126/science.184.4136.572
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Articles

Brain Capillary Blockage Produced by a Virulent Strain of Rodent Malaria

Meir Yoeli 1 and Bruce J. Hargreaves 1

1 Department of Preventive Medicine, New York University School of Medicine, New York 10016

A sudden enhancement in virulence of a mild Plasmodium berghei yoelii 17 x strain resulted in fulminating and fatal infections in CF1 and A/J mice. The virulent strain has maintained its characteristics after ten cyclical transmissions through Anopheles stephensi. The visible expression of virulence of the mutated strain is its ability to cross the blood-brain barrier and cause intravascular sequestration of injected erythrocytes and blockage of brain capillaries. We, therfore, believe that the virulent line of Plasmodium berghei yoelii 17 x could serve as a useful laboratory model for the study of "cerebral malaria."


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Cerebral Malaria in Mice : Interleukin-2 Treatment Induces Accumulation of {{gamma}}{{delta}} T Cells in the Brain and Alters Resistant Mice to Susceptible-Like Phenotype.
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Am. J. Pathol. 158, 163-172
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Science. ISSN 0036-8075 (print), 1095-9203 (online)