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Science 26 April 1974:
Vol. 184. no. 4135, pp. 473 - 475
DOI: 10.1126/science.184.4135.473
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Articles

Fate of agr-Bungarotoxin Bound to Acetylcholine Receptors of Normal and Denervated Muscle

Darwin K. Berg 1 and Zach W. Hall 1

1 Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115

In organ culture, agr-[125I]bungarotoxin bound to extrajunctional receptors of denervated muscle is lost from the tissue at a more rapid rate than the toxin bound to the junctional receptors of normal muscle. The rapid loss of toxin from denervated muscle can be blocked by inhibitors of energy production and protein synthesis, and may reflect turnover of the toxin-receptor complex in the membrane.


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