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Science 12 April 1974:
Vol. 184. no. 4133, pp. 177 - 179
DOI: 10.1126/science.184.4133.177
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Articles

Dopamine Nerve Terminals in the Rat Limbic Cortex: Aspects of the Dopamine Hypothesis of Schizophrenia

T. Hökfelt 1, Å. Ljungdahl 1, K. Fuxe 1, and O. Johansson 1

1 Department of Histology, Karolinska Institutet, 104 01 Stockholm, Sweden

The existence of cortical dopamine nerve terminals is demonstrated with a highly sensitive modification of the Falck-Hillarp fluorescence technique. This confirms previous biochemical reports of high dopamine levels in the cortex. The histochemistry reveals that the distribution is regional and confined to the limbic cortex.


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