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Science 12 April 1974:
Vol. 184. no. 4133, pp. 175 - 177
DOI: 10.1126/science.184.4133.175
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Articles

Norepinephrine-Sensitive Adenylate Cyclases in Rat Brain: Relation to Behavior and Tyrosine Hydroxylase

Phil Skolnick 1 and John W. Daly 1

1 National Institute of Arthritis, Metabolism and Digestive Diseases, Bethesda, Maryland 20014

Responses of norepiniephrine sensitive adeniosinie 3',5'-monophosphate (cyclic AMP)-generating systems in combined midbrain-striatal slices of four rat strains correlate positively with spontaneous behavioral activity and negatively with levels of midbrain and striatal tyrosine hydroxylase. Responses of cerebral cortical norepinephrine-sensitive cyclic AMP systems correlate negatively with spontaneous behavioral activity antd positively with midbrain and striatal tyrosine hydroxylase. Such correlations were not found with responses of the cyclic AMP- generatinlg systems to isoproterenol, adenosine. veratridine or of an adenosne and norepinephrine combination.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Strain differences in rat brain epinephrine synthesis: regulation of alpha-adrenergic receptor number by epinephrine.
B. Perry, J. Stolk, G Vantini, R. Guchhait, and D. U'Prichard (1983)
Science 221, 1297-1299
   Abstract »    PDF »
Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity.
D. Segal, M. Geyer, and B. Weiner (1975)
Science 189, 301-303
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)