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Science 12 April 1974:
Vol. 184. no. 4133, pp. 169 - 171
DOI: 10.1126/science.184.4133.169
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Articles

Benzo[a]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography

James K. Selkirk 1, Robert G. Croy 1, and Harry V. Gelboin 1

1 Molecular Carcinogenesis Section, Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014

High-pressure liquid chromatography can separate eight metabolites of benzo[a] pyrene formed by rat liver microsomes. This method offers major advantages over previous techniques used for the separation of oxygenated polycyclic aromatic hydrocarbons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.
D. Schwarz, P. Kisselev, I. Cascorbi, W.-H. Schunck, and I. Roots (2001)
Carcinogenesis 22, 453-459
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"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide.
J. N. PITTS JR., D. M. LOKENSGARD, P. S. RIPLEY, K. A. VAN CAUWENBERGHE, L. VAN VAECK, S. D. SHAFFER, A. J. THILL, and W. L. BELSER JR. (1980)
Science 210, 1347-1349
   Abstract »    PDF »
Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.
S. Yang, D. McCourt, J. Leutz, and H. Gelboin (1977)
Science 196, 1199-1201
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Science. ISSN 0036-8075 (print), 1095-9203 (online)