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Science 12 April 1974:
Vol. 184. no. 4133, pp. 163 - 165
DOI: 10.1126/science.184.4133.163
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Articles

Pineal Gland: 24-Hour Rhythm in Norepinephrine Turnover

Michael Brownstein 1 and Julius Axelrod 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

There is a 24-hour rhythm in the turnover of norepinephrine in sympathetic nerves innervating the pineal gland. This rhythm persists in blinded animals but is suppressed in normnal rats by light. The rhythm in norepinephrine turnover generates the rhythums in pineal indoleamines and N-acetyltransferase.


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