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Science 12 April 1974:
Vol. 184. no. 4133, pp. 160 - 161
DOI: 10.1126/science.184.4133.160
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Articles

Metabolic Differences between Normal and Neoplastic Cells: Effects of Aminonucleoside on Cytoplasmic Messenger RNA

Jolanta J. Cholon 1 and George P. Studzinski 1

1 Department of Pathology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Treatment of cultured normal human fibroblasts with an adenosine analog (aminonucleoside of puromycin) rapidly inhibits the appearance of cytoplasmic messenger RNA, identified by its polyadenylate sequence. Similar treatment of SV40-transformed fibroblasts does not lead to such an inhibition. Cordycepin. another analog of adenosine. inlhibits polyadenylate-containing cytoplasmic RNA in both types of cell.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)