Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 April 1974:
Vol. 184. no. 4133, pp. 158 - 160
DOI: 10.1126/science.184.4133.158
Prev | Table of Contents | Next

Articles

Dexamethasone Stimulation of Murine Mammary Tumor Virus Expression: A Tissue Culture Source of Virus

Wade P. Parks 1, Edward M. Scoinick 1, and Edmund H. Kozikowski 2

1 Ntional Cancer Institute, Bethesda. Maryland 20014
2 Meloy Laboratories, Rockville, Maryland 20850

In mouse cell lines derived from mammary adenocarcinomnas, the synthetic steroid dexamnethasone stimulates production of murine mammary tumor virus. Viral RNA and antigens are increased as much as 20-fold, and culture fluid supernatants from steroid-treated cells contain type B particles with reverse transcriptase. These cells provide a possible tissue culture source of this virus and a model system for studying the mechanism of action of corticosteroids and the regulation of transcription of integrated viral DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear Matrix Binding Regulates SATB1-mediated Transcriptional Repression.
J. Seo, M. M. Lozano, and J. P. Dudley (2005)
J. Biol. Chem. 280, 24600-24609
   Abstract »    Full Text »    PDF »
Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells.
T. Suzuki, M. Yamaya, K. Sekizawa, N. Yamada, K. Nakayama, S. Ishizuka, M. Kamanaka, T. Morimoto, Y. Numazaki, and H. Sasaki (2000)
Am J Physiol Lung Cell Mol Physiol 278, L560-L571
   Abstract »    Full Text »    PDF »
Diminished Aqueous Microviscosity of Tumors in Murine Models Measured with in Vivo Radiofrequency Electron Paramagnetic Resonance.
H. J. Halpern, G. V. R. Chandramouli, E. D. Barth, Cheng Yu, Miroslav Peric, D. J. Grdina, and B. A. Teicher (1999)
Cancer Res. 59, 5836-5841
   Abstract »    Full Text »    PDF »
The steroid and thyroid hormone receptor superfamily.
R. Evans (1988)
Science 240, 889-895
   Abstract »    PDF »
Mammary Tumor Virus DNA: A Glucocorticoid-responsive Transposable Element.
K. R. Yamamoto, M. R. Stallcup, J. Ring, and G. M. Ringold (1978)
Cold Spring Harb Symp Quant Biol 42, 625-638
   Abstract »    PDF »
Glucocorticoid Induction of Murine Mammary Tumor Virus In Vitro.
W. P. Parks, E. M. Scolnick, and J. C. Ransom (1974)
Cold Spring Harb Symp Quant Biol 39, 1151-1158
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)