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Science 5 April 1974:
Vol. 184. no. 4132, pp. 85 - 86
DOI: 10.1126/science.184.4132.85
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Articles

Prolactin Receptors in an Estrogen Receptor-Deficient Mammary Carcinoma

M. E. Costlow 1, R. A. Buschow 1, and W. L. McGuiri 1

1 Department of Medicine, University of Texas Medical School, San Antonio 78284

We demonstrate for the first time the presence of specific high-affinity receptors for prolactin in rat mammayy carcinoma. There appear to be no significant differences between normal rat mammary tissue and the transplantable, estrogen receptor-deficient R3230AC tumor with regard to the number of binding sites, the affinity of the receptor for prolactin, or the specificity of binding.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)