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Science 5 April 1974:
Vol. 184. no. 4132, pp. 73 - 75
DOI: 10.1126/science.184.4132.73
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Articles

Myelin Basic Protein: Location of Multiple Independent Antigenic Regions

Bernard F. Driscoll 1, Allan J. Kramer 1, and Marian W. Kies 1

1 Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014

Immnunization of guinea pigs with homologous myelin basic protein induces antibodies that differ in their ability to bind specific peptide fragments of the protein. Antiserums with differing specificities made it possible to demonstrate at least three mutually exclusive antigenic sites in the protein molecule. One of these sites is located between residues 44 and 89, another between 90 and 116, and the third between 117 and 170.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein.
L. Sires, S Hruby, E. Alvord Jr, I Hellstrom, K. Hellstrom, M. Kies, R Martemspm, G. Deibler, E. Beckman, and J. Casnellie (1981)
Science 214, 87-89
   Abstract »    PDF »
Autoimmune Diseases in Animals: Useful Models for Immunology.
G. B. Kolata (1974)
Science 184, 1360-1362
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)