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Science 5 April 1974:
Vol. 184. no. 4132, pp. 66 - 68
DOI: 10.1126/science.184.4132.66
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Articles

ggr-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino Acids

Marian Orlowski 1, Grazia Sessa 1, and Jack Peter Green 1

1 Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York. New York 10029

A fraction containing capillaries and rich in ggr-glutamyl transpeptidase was isolated from homogenates of bovine brain cortex by density gradient centrifugation. The enzyme was localized in the endothelial cells by a histochemical procedure. ggr-Glutantyl transpeptidase may function in the transfer of some amino acids across the blood-brain barrier.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)