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Science 15 March 1974:
Vol. 183. no. 4129, pp. 1092 - 1094
DOI: 10.1126/science.183.4129.1092
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Articles

Calcium Absorption and Calcium-Binding Protein Synthesis: Solanum malacoxylon Reverses Strontium Inhibition

R. H. Wasserman 1

1 Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca, New York 14850

The ingestion of diets containing high concentrations of stable strontium inhibits calcium absorption and intestinal calcium-binding protein synthesis and, as shown by others, does so by inhibiting the conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, the active form of vitamin D. The addition of the South American plant Solanum malacoxylon to strontium-containing diets counteracts the inhibitory action of dietary strontium, thereby indicating that the plant contains a factor which can mimic the action of 1,25-dihydroxycholecalciferol and representing the first such factor identified in a botanical source.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcinogenic factor in Solanum malacoxylon: evidence that it is 1,25-dihydroxyvitamin D3-glycoside.
R. Wasserman, J. Henion, M. Haussler, and T. McCain (1976)
Science 194, 853-855
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Science. ISSN 0036-8075 (print), 1095-9203 (online)