Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 March 1974:
Vol. 183. no. 4129, pp. 1085 - 1087
DOI: 10.1126/science.183.4129.1085
Prev | Table of Contents | Next

Articles

Arachidonic Acid Causes Sudden Death in Rabbits

Melvin J. Silver 1, Willis Hoch 1, James J. Kocsis 1, Carol M. Ingerman 1, and J. Bryan Smith 1

1 Cardeza Foundation and Departments of Pharmacology and Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Injection of sodium arachidonate (1.4 milligrams per kilogram) into the marginal ear veins of rabbits caused death within 3 minutes. Histological examination showed platelet thrombi in the microvasculature of the lungs. Rabbits were protected from the lethal effects of arachidonic acid by pretreatment with aspirin. Fatty acids closely related to arachidonic acid did not cause death.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Platelets : Unindicted Coconspirators in Inflammatory Tissue Injury.
A. M. Lefer (2000)
Circ. Res. 87, 1077-1078
   Full Text »    PDF »
Inhibitory Effects of TA-993, a New 1,5-Benzothiazepine Derivative, on Platelet Aggregation.
A. Odawara, K. Kikkawa, M. Katoh, H. Toryu, T. Shimazaki, and Y. Sasaki (1996)
Circ. Res. 78, 643-649
   Abstract »    Full Text »
Final Report on the Safety Assessment of Arachidonic Acid.
(1993)
International Journal of Toxicology 12, 481-506
   Abstract »    PDF »
Appendix to the Report on Arachidonic Acid.
(1993)
International Journal of Toxicology 12, 507-559
   PDF »
Prophylaxis of Atherosclerosis with Marine Omega-3 Fatty Acids: A Comprehensive Strategy.
C. VON SCHACKY (1987)
Ann Intern Med 107, 890-899
   Abstract »    PDF »
Thromboxanes: selective biosynthesis and distinct biological properties.
P Needleman, M Minkes, and A Raz (1976)
Science 193, 163-165
   Abstract »    PDF »
Nicotinic acid reduction of plasma volume loss after thermal trauma.
J. Hilton and C. Wells (1976)
Science 191, 861-862
   Abstract »    PDF »
Stroke in rats produced by carotid injection of sodium arachidonate.
T. Furlow Jr and N. Bass (1975)
Science 187, 658-660
   Abstract »    PDF »
Pulmonary Platelet Aggregates Associated with Sudden Death in Man.
H. Pirkle and P. Carstens (1974)
Science 185, 1062-1064
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)