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Science 22 February 1974:
Vol. 183. no. 4126, pp. 749 - 753
DOI: 10.1126/science.183.4126.749
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Articles

Partial Purification of an Opiate Receptor from Mouse Brain

Louise I. Lowney 1, Karin Schulz 1, Patricia J. Lowery 1, and Avram Goldstein 1

1 Department of Pharmacology, Stanford University Medical Center, Stanford, California 94305, and Addiction Research Foundation, Palo Alto, California 94304

A proteolipid isolated from a lipid extract of mouse brain demonstrates stereospecific binding properties for levorphanol. It is present only in neuronal tissue and most abundant in the rhombencephalon. One component saturates at a concentration corresponding to maximum pharmacologic effect in vivo. The estimated mass is 60,000 daltons per bound opiate molecule.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endorphins in Septic Shock: Hemodynamic and Endocrine Effects of an Opiate Receptor Antagonist and Agonist.
F. N. Gahhos, R. C. J. Chiu, E. J. Hinchey, and G. K. Richards (1982)
Arch Surg 117, 1053-1057
   Abstract »    PDF »
Antibodies to cerebroside sulfate inhibit the effects of morphine and beta-endorphin.
F. Craves, B Zalc, L Leybin, N Baumann, and H. Loh (1980)
Science 207, 75-76
   Abstract »    PDF »
Endogenous opiate receptor ligand: electrically induced release in the guinea pig ileum.
M. Puig, P Gascon, G. Craviso, and J. Musacchio (1977)
Science 195, 419-420
   Abstract »    PDF »
The Opiate Receptor.
S. H. SNYDER, C. B. PERT, and G. W. PASTERNAK (1974)
Ann Intern Med 81, 534-540
   Abstract »    PDF »
Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the Rat.
Y. F. Jacquet and A. Lajtha (1974)
Science 185, 1055-1057
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)