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Science 8 February 1974:
Vol. 183. no. 4124, pp. 534 - 536
DOI: 10.1126/science.183.4124.534
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Articles

Tumor Development after 3-Methylcholanthrene in Immunologically Deficient Athymic-Nude Mice

Osias Stutman 1

1 Memorial Sloan-Kettering Cancer Center, New York 10021

Athymic-nude (nu/nu) mice and normal (nu/+) mice showed no differences in either latent period or incidence of local sarcomas or lung adenomas within 120 days after administration of 3-methylcholanthrene at birth. However, nu/nu mice were incapable of rejecting allogeneic skin grafts for the duration of the experiment. These results argue against an active role of thymus-dependent immunity as a surveillance mechanism preventing tumor development.


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