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Science 8 February 1974:
Vol. 183. no. 4124, pp. 532 - 533
DOI: 10.1126/science.183.4124.532
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Articles

Cyclic Adenosine Monophosphate: Selective Increase in Caudate Nucleus after Administration of L-Dopa

E. Garelis 1 and N. H. Neff 1

1 Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032

Treatment with the dopamine precursor L-dopa produced a significant accumulation of adenosine 3',5'-monophosphate (cyclic AMP) in the caudate nucleus of the rat. In contrast, there was no change in the amount of cyclic AMP in the cerebellum. Accumulation of cyclic AMP in the caudate nucleus after administration of L-dopa was prevented by prior treatment with the decarboxylase inhibitor RO 4-4602. These observations and those in other laboratories support the assumption that dopamine formed from L-dopa selectively activates striatal adenylate cyclase. The in vivo activation of adenylate cyclase after treatment with L-dopa may be a useful model for studying neurological and psychiatric disorders that are thought to involve the dopaminergic system of the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenosine 3',5'-Monophosphate Content in Rat Caudate Nucleus: Demonstration of Dopaminergic and Adrenergic and Receptors.
J. Forn, B. K. Krueger, and P. Greengard (1974)
Science 186, 1118-1120
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Science. ISSN 0036-8075 (print), 1095-9203 (online)