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Science 8 February 1974:
Vol. 183. no. 4124, pp. 526 - 528
DOI: 10.1126/science.183.4124.526
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Articles

Paradoxical Increase in Rate of Catabolism of Low-Density Lipoproteins after Hepatectomy

Allan D. Sniderman 1, Thomas E. Carew 1, James G. Chandler 1, and Daniel Steinberg 1

1 Division of Metabolic Disease, Departments of Medicine and Surgery, University of California, San Diego, School of Medicine, La Jolla 92037

It has been suggested that the liver may be a major site for irreversible degradation of low-density lipoprotein (LDL). The disappearance of autologous 125I-labeled LDL from plasma was compared in intact and in hepatectomized swine. Contrary to expectations, the rate of irreversible removal of LDL from plasma was increased rather then decreased by hepatectomy. These studies suggest that the liver is not a major site for LDL removal. We propose further that the liver (or some function requiring an intact liver) may affect the metabolism of LDL in a manner that prolongs its lifetime in the plasma compartment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High Density Lipoprotein Inhibits Low Density Lipoprotein Binding and Uptake by Bovine Aortic Endothelial Cells.
J. J. Alexander, R. Miguel, and D. Graham (1990)
Angiology 41, 1065-1069
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Receptor-mediated control of cholesterol metabolism.
M. Brown and J. Goldstein (1976)
Science 191, 150-154
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