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Science 8 February 1974:
Vol. 183. no. 4124, pp. 520 - 521
DOI: 10.1126/science.183.4124.520

Articles

Toxaphene Insecticide: A Complex Biodegradable Mixture

John E. Casida 1, Roy L. Holmstead 1, Safy Khalifa 1, John R. Knox 1, Tomihiko Ohsawa 1, Kenneth J. Palmer 2, and Rosalind Y. Wong 2

1 Division of Entomology and Parasitology, University of California, Berkeley 94720
2 Western Regional Research Center, U.S. Department of Agriculture, Albany, California 94710

Adsorption and gas-liquid chromatography separate toxaphene into at least 175 polychlorinated 10-carbon compounds including Cl6, Cl7, Cl8, Cl9, and Cl10 derivatives. One toxic component is 2,2,5-endo,6-exo,8,9,10-heptachlorobornane. Rats metabolically dechlorinate toxaphene, removing about half of the chlorine from the technical insecticide and from each of seven subfractions of varying composition and toxicity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polychlorobornane components of toxaphene: structure-toxicity relations and metabolic reductive dechlorination.
M. Saleh, W. Turner, and J. Casida (1977)
Science 198, 1256-1258
   Abstract »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)