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Science 1 February 1974:
Vol. 183. no. 4123, pp. 422 - 424
DOI: 10.1126/science.183.4123.422
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Articles

High-Frequency C-Type Virus Induction by Inhibitors of Protein Synthesis

Stuart A. Aaronson 1 and Claire Y. Dunn 2

1 Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014
2 Hazleton Laboratories, Inc., Vienna, Virginia 22180

When inhibitors of protein synthesis are added to BALB/c mouse cells in culture, induction of naturally integrated C-type RNA virus occurs in a high percentage of cells. The action of protein synthesis inhibitors differs from that of halogenated pyrimidines, another class of virus inducers, in their effects on biologically distinguishable viruses. The use of such inhibitors to study integrated virus expression provides a means for studying gene regulation in mammalian cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure and Infectivity of Integrated Murine Leukemia Virus DNA.
D. R. Lowy, E. Rands, S. K. Chattopadhyay, and G. L. Hager (1980)
Cold Spring Harb Symp Quant Biol 44, 1143-1151
   Abstract »    PDF »
Isolation of type C virions from a normal human fibroblast strain.
S Panem, E. Prochownik, F. Reale, and W. Kirsten (1975)
Science 189, 297-299
   Abstract »    PDF »
Genetic Control of the Expression of Murine Leukemia Virus Proteins in Tissues of Normal, Young Adult Mice.
M. Strand, F. Lilly, and J. T. August (1974)
Cold Spring Harb Symp Quant Biol 39, 1117-1122
   Abstract »    PDF »
Differential Cellular Regulation of Three Distinct Classes of Type C RNA Viruses Endogenous to Mouse Cells.
S. A. Aaronson and J. R. Stephenson (1974)
Cold Spring Harb Symp Quant Biol 39, 1129-1137
   Abstract »    PDF »
Glucocorticoid Induction of Murine Mammary Tumor Virus In Vitro.
W. P. Parks, E. M. Scolnick, and J. C. Ransom (1974)
Cold Spring Harb Symp Quant Biol 39, 1151-1158
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)