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Science 25 January 1974:
Vol. 183. no. 4122, pp. 327 - 330
DOI: 10.1126/science.183.4122.327
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Articles

Acetylenic Analog of Arachidonate That Acts Like Asprinn on Platelets

A. L. Willis 1, D. C. Kuhn 1, and H. J. Weiss 2

1 Department of Pharmacology, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
2 Department of Medicine, Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York 10019

Development of irreversible platelet aggregation and the accompanying release of platelet-bound serotonin and production of prostaglandins is suppressed by 5,8,11,14-eicosatetraynoic acid (TYA). These findings may be explained by an ability of TYA to inhibit the enzymatic conversion of arachidonate to a newly recognized factor, labile aggregation-stimulating substance, which induces platelet aggregation, and to prostaglandins E2 and F2agr.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin.
A. L. Willis (1974)
Science 183, 325-327
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