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Science 25 January 1974:
Vol. 183. no. 4122, pp. 325 - 327
DOI: 10.1126/science.183.4122.325
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Articles

An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin

Anthony L. Willis 1

1 Department of Pharmacology, Hoffmann—La Roche, Inc., Nutley, New Jersey 07110

Aspirin-type drugs may inhibit irreversible clumping of human blood platelets by blocking the enzymatic conversion of arachidonic acid to a hitherto undiscovered factor, labile aggregation-stimulating substance, which triggers aggregation and to prostaglandin E2, which sensitizes the platelets to its aggregatory effects.


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