Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 January 1974:
Vol. 183. no. 4121, pp. 212 - 213
DOI: 10.1126/science.183.4121.212
Prev | Table of Contents | Next

Articles

DNA Synthesis and Mitosis in Well-Differentiated Mammalian Cardiocytes

Margaret A. Goldstein 1, William C. Claycomb 1, and Aarnold Schwartz 1

1 Department of Cell Biophysics, Baylor College of Medicine, Houston, Texas

Incorporation of [3H]thymidine into nuclei of heart cells of 2-day-old rats indicates that neonatal cardiac cells containing well-aligned myofibrils synthesize DNA. In these highly differentiated cells, neither the presence of contractile proteins nor their organization into myofibrils inhibits either DNA synthesis or mitosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
p300 Protein as a Coactivator of GATA-5 in the Transcription of Cardiac-restricted Atrial Natriuretic Factor Gene.
T. Kakita, K. Hasegawa, T. Morimoto, S. Kaburagi, H. Wada, and S. Sasayama (1999)
J. Biol. Chem. 274, 34096-34102
   Abstract »    Full Text »    PDF »
E2F-1 Overexpression in Cardiomyocytes Induces Downregulation of p21CIP1 and p27KIP1 and Release of Active Cyclin-Dependent Kinases in the Presence of Insulin-Like Growth Factor I.
R. von Harsdorf, L. Hauck, F. Mehrhof, U. Wegenka, M. C. Cardoso, and R. Dietz (1999)
Circ. Res. 85, 128-136
   Abstract »    Full Text »    PDF »
Transcriptional Coactivator p300 Stimulates Cell Type-specific Gene Expression in Cardiac Myocytes.
K. Hasegawa, M. B. Meyers, and R. N. Kitsis (1997)
J. Biol. Chem. 272, 20049-20054
   Abstract »    Full Text »    PDF »
DNA synthesis in cultured adult cardiocytes.
M Cantin, M Ballak, J Beuzeron-Mangina, M. Anand-Srivastava, and C Tautu (1981)
Science 214, 569-570
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)