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Science 18 January 1974:
Vol. 183. no. 4121, pp. 212 - 213
DOI: 10.1126/science.183.4121.212
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Articles

DNA Synthesis and Mitosis in Well-Differentiated Mammalian Cardiocytes

Margaret A. Goldstein 1, William C. Claycomb 1, and Aarnold Schwartz 1

1 Department of Cell Biophysics, Baylor College of Medicine, Houston, Texas

Incorporation of [3H]thymidine into nuclei of heart cells of 2-day-old rats indicates that neonatal cardiac cells containing well-aligned myofibrils synthesize DNA. In these highly differentiated cells, neither the presence of contractile proteins nor their organization into myofibrils inhibits either DNA synthesis or mitosis.


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E2F-1 Overexpression in Cardiomyocytes Induces Downregulation of p21CIP1 and p27KIP1 and Release of Active Cyclin-Dependent Kinases in the Presence of Insulin-Like Growth Factor I.
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Transcriptional Coactivator p300 Stimulates Cell Type-specific Gene Expression in Cardiac Myocytes.
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DNA synthesis in cultured adult cardiocytes.
M Cantin, M Ballak, J Beuzeron-Mangina, M. Anand-Srivastava, and C Tautu (1981)
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