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Science 18 January 1974:
Vol. 183. no. 4121, pp. 208 - 210
DOI: 10.1126/science.183.4121.208
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Articles

Ethane Evolution: A New Index of Lipid Peroxidation

Caroline A. Riely 1, Gerald Cohen 1, and Morris Lieberman 2

1 College of Physicians and Surgeons, Colunmbia University, New York 10032
2 U.S. Department of Agriculture, Agricultural Research Service, Beltsville, Maryland 20705

Homogenates of mouse liver and brain at 37°C spontaneously formed lipid peroxides and simultaneously evolved ethane. agr-Tocopherol, a lipid antioxidant, blocked ethane formation. When mice were injected with carbon tetrachloride (a liquid prooxidant for liver), the animals produced ethane. Ethane evolution in vivo was stimulated by prior administration of phenobarbital and it was diminished by prior injection of agr-tocopherol. These data suggest that ethane production may be a useful index of lipid peroxidation in tissue homogenates and in intact animals.


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