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Science 11 January 1974:
Vol. 183. no. 4120, pp. 87 - 88
DOI: 10.1126/science.183.4120.87
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Articles

In vivo Inhibition of Growth of Two Hormone-Dependent Mammary Tumors by Dibutyryl Cyclic AMP

Yoon Sang Cho-Chung 1 and Pietro M. Gullino 1

1 Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014

Growth of hormone-dependent rat mammary tumors was arrested in vivo by N6,O2'-dibutyryl cyclic adenosine 3',5'-monophosphate. Estrogen concentration did not change, but acid ribonuclease activity and synthesis increased during treatment with the dibutyryl cyclic nucleotide, as was shown during tumor regression due to hormonal deprivation. Growth arrest, thus, appears to derive from enhanced tissue catabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Chorionic Gonadotropin Decreases Proliferation and Invasion of Breast Cancer MCF-7 Cells by Inhibiting NF-{kappa}B and AP-1 Activation.
Ch. V. Rao, X. Li, S. K. Manna, Z. M. Lei, and B. B. Aggarwal (2004)
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Dibutyryl cyclic AMP mimics ovariectomy: nuclear protein phosphorylation in mammary tumor regression.
Y. Cho-Chung and B. Redler (1977)
Science 197, 272-275
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Sesquiterpene antitumor agents: inhibitors of cellular metabolism.
K. Lee, I. Hall, E. Mar, C. Starnes, S. ElGebaly, T. Waddell, R. HADGRAFT, C. Ruffner, and I Weidner (1977)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)