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Science 11 January 1974:
Vol. 183. no. 4120, pp. 83 - 84
DOI: 10.1126/science.183.4120.83
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Articles

Transplantation of Allogeneic Bone Marrow in Canine Cyclic Neutropenia

David C. Dale 1 and Robert G. Graw Jr. 2

1 Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Experimental Hematology Section, Pediatric Oncology Branch. National Cancer Institute, Bethesda, Maryland 20014

Transplantation of normal bone marrow cells to a gray collie dog with cyclic neutropenia resulted in normal granulocytopoiesis. The finding suggests that cyclic neutropenia occurs because the hematopoietic stem cells are defective. Because of the similarity of human and canine cyclic neutropenia, it also suggests that the human disease may be curable by marrow transplantation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery.
O. Yanay, S. C. Barry, L. J. Katen, M. Brzezinski, L. Y. Flint, J. Christensen, D. Liggitt, D. C. Dale, and W. R. A. Osborne (2003)
Blood 102, 2046-2052
   Abstract »    Full Text »    PDF »
Cyclical Neutropenia and Other Periodic Hematological Disorders: A Review of Mechanisms and Mathematical Models.
C. Haurie, D. C. Dale, and M. C. Mackey (1998)
Blood 92, 2629-2640
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)