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Science 28 December 1973:
Vol. 182. no. 4119, pp. 1355 - 1356
DOI: 10.1126/science.182.4119.1355
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Articles

Acute Lymphoblastic Leukemic Cells with T (Thymus-Derived) Lymphocyte Markers

John H. Kersey 1, Andrej Sabad 1, Kazimiera Gajl-Peczalska 1, Helen M. Hallgren 1, Edmond J. Yunis 1, and Mark E. Nesbit 1

1 Departments of Laboratory Medicine and Pathology, and Pediatrics, University of Minnesota, Minneapolis 55455

Five of nine children with acute lymphoblastic leukemia had lymphoblasts that bound sheep erythrocytes or reacted with antiserum to thymocytes, suggesting involvement of T (thymus-derived) cells. When lymphoblasts from all patients were examined by immunofluorescence they were found to lack a marker for B (bone marrow or bursa-equivalent) cells, that is, the presence of surface immunoglobulins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia.
J. H. Kersey (1997)
Blood 90, 4243-4251
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Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen.
I. Bernstein, M. Tam, and R. Nowinski (1980)
Science 207, 68-71
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Acute Leukemia: Biology and Treatment.
M. J. CLINE, D. W. GOLDE, R. J. BILLING, J. E. GROOPMAN, J. ZIGHELBOIM, and R. P. GALE (1979)
Ann Intern Med 91, 758-773
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Convoluted Lymphocytic Lymphoma in Adults: A Clinicopathologic Entity.
P. J. ROSEN, D. I. FEINSTEIN, P. K. PATTENGALE, B. H. TINDLE, A. H. WILLIAMS, M. J. CAIN, J. B. BONORRIS, J. W. PARKER, and R. J. LUKES (1978)
Ann Intern Med 89, 319-324
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Histiocytic Medullary Reticulosis in Acute Lymphocytic Leukemia of T Cell Origin.
T. K. Chen, M. E. Nesbit, R. McKenna, and J. H. Kersey (1976)
Arch Pediatr Adolesc Med 130, 1262-1264
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Meningeal Mycosis Fungoides: Clinical and Cellular Characteristics.
T. W. HAUCH, J. D. SHELBOURNE, H. J. COHEN, D. MASON, and W. B. KREMER (1975)
Ann Intern Med 82, 499-505
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T and B Lymphocytes in Atopic Eczema.
J. R. Luckasen, A. Sabad, R. W. Goltz, and J. H. Kersey (1974)
Arch Dermatol 110, 375-377
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How Clinically Useful is T and B Cell Quantitation?.
J. WYBRAN and H. FUDENBERG (1974)
Ann Intern Med 80, 765-767
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Response of B and T Lymphocytes and Other Blood Leukocytes in Chickens with Marek's Disease.
L. N. Payne, P. C. Powell, and M. Rennie (1974)
Cold Spring Harb Symp Quant Biol 39, 817-826
   Abstract »    PDF »


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